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Hello mate, you want to ride faster? Are you powerless?nWant to be faster than lance strong? Be fast and use Energy Noodles!nwww.energynoodles.comnn0.0 nutrirition male hormons are more powerful than chock norrisnSecret injection total legal then you can be faster than a Ferrari!nYour male testosterone will be faster than a rocketnnUse it like a professional and you will get a Mega Bonus!nENERGY NOODLES GIVES YOU CLEAN VIRGIN PEE!! nnFrom the manufacturers of Boss Noodles, Do Ping Province China
⏲ 32 sec ✓ 13-Jun-2013
South China Morning Post
⏲ 2 minutes 1 second 👁 2.7M
WION
⏲ 3 minutes 10 seconds 👁 337.4K
Bare Faces Aesthetics and Laser Clinic has opened in Rhino's Gym, Ryhall Road, Stamford. The owner, Sasha Stones, is a qualified aesthetics practitioner.
⏲ 0:40 👁 1.8M
CGTN
⏲ 35 seconds 👁 2.6K
New China TV
⏲ 37 seconds 👁 965
MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>
⏲ 1:42 👁 10K
DW News
⏲ 13 minutes 8 seconds 👁 26.1K
Dr.AZIZBEK
⏲ 52 seconds 👁 130.6K
Mayku is a new British hardware startup backed by Innovate UK, the Arts Council and the Design Council. They build desktop factories. Founded by Benjamin Redford - a designer and inventor. And Alex Smilansky - a product designer and digital strategist in June 2015. nnThe idea for Mayku was formed while Ben was developing Projecteo - the tiny Instagram projector. His experience of designing a product in London, manufacturing it in China and reshipping it all over the world from the US had a lasti
⏲ 1 min 20 sec ✓ 05-Jan-2016
Dr.AZIZBEK
⏲ 29 seconds 👁 186.6K
Insight Medical Imaging
⏲ 6 minutes 15 seconds 👁 316
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